GLUE Monte Rosa Therapeutics Inc

$GLUE Any flippers / quick money types might be tempted here watching for a (temporary) base and volume to dry up then harvest a quick 7% Blip up on no news and for no reason. but the 6 month chart is ugly and I dont see a plateau yet, but volume may be diminishing. I think the tide of the overall market is down and out so that to me is the overriding force so going to need some impressive news or positive surprise. Recall just 5-6 years ago it was not uncommon for biotechs to drift down for 2-3 painful years and have market caps 50% of their cash.. Why kind of news and trade volume would GLUE need to pop 50% and work its way back up through bagholders above this price? I think its possible, just not yet. Good luck

$GLUE from 10.75 to 10.17 is basically a red day. just sit on this and pick up maybe 9’s but could see $8 end of year

$GLUE you don’t stick around after a 20% pop for phase 1 data. That’s a rule. If you miss out you just had bad luck and move on

$GLUE If you are playing with house money thats great. I think we see another 30-40% price drop / sell off for most of these biotechs by Christmas. I also see a snowball effect on many of these that drifted down all year going off a cliff for no reason...thats the time to think about buying. As posted many times, I see a lot of shortages / chaos / forced control coming, none of it good for biotech. On the other hand, Well timed buys and sells in the meantime might help one gain a quick 8-10% on bounces (for example, maybe GLUE next week) but look at these GLUE CCCC even faves TNGS and ERAS - the trend is down. Look at the slopes of the selling and the concommitant volume - I think there is a ways to go. Good luck.

$GLUE Congrats longs. GFORCE-1 should ease the post-ZEUS overhang and supports mgmt's move into Phase 2. MRT-8102 hit the same systemic markers the IL-6 antibodies did (hsCRP -85%, IL-6 -54%) PLUS upstream plaque DAMPs they don't reach (calprotectin -55% vs ~flat placebo, S100A12 -46%, SAA -51%). Back to healthy-volunteer levels, not suppressed below. Low-dose safety excellent: 5mg had zero discontinuations and fewer AEs than placebo (26% vs 30%), with the same effect as 40mg. No SAEs, no infection signal. An oral small molecule doing what injectable biologics attempt could be a paradigm shift. ASCVD TAM: ~14M US CAD pts, ~4M+ with residual inflammatory risk. Illustrative: 5-10% share at ~$5K/yr = $1-2B/yr US alone. Eyes open: outcomes unproven; GFORCE-2 slipped to H1'27, FAI imaging next. NFAD/DYOR

$GLUE $MLYS $VERA Props 🙌👌 to this fellow for always knowing where to be in the land of broken obscurity That is some kinda talent.

$GLUE interesting take. That is quite a drawdown if you believe it could get that low. Where do you see 30-40% drops coming from?

$GLUE— GFORCE-1 data tomorrow, 8AM ET. The market has heavily discounted MRT-8102, IMO partly because of recently reported downstream clinical failures across inflammatory pathways. Tomorrow should help answer whether the market is throwing the upstream NEK7/NLRP3 mechanism into the same bucket. MRT-8102 is different mechanistically: a once-daily oral molecular glue degrader targeting NEK7, shutting down NLRP3 inflammasome signaling upstream of IL-1β → IL-6 → CRP rather than simply blocking one downstream cytokine. The initial 40mg data set a high bar: • 85% median hsCRP reduction at 4 weeks • 94% achieved hsCRP <2 mg/L • ~80–90% NEK7 degradation • IL-1β suppression + 55% median endogenous IL-6 reduction • Favorable safety profile to date Tomorrow we get expanded GFORCE-1 dose exploration, which matters because the real question isn’t simply whether CRP falls again — we already have that signal. What I’m watching: • Dose-response and CRP depth at the new doses • Durability/no rebound through Week 4 • Evidence beyond CRP — especially DAMP/inflammatory markers such as calprotectin/HMGB1 if reported • Clean infection/liver safety • PK/PD relationship between dose → NEK7 degradation → downstream inflammation • GFORCE-2 timing Why it matters: the opportunity extends well beyond one ASCVD study. • ASCVD — enormous residual inflammatory-risk population • Gout — ~9M U.S. adults • Hidradenitis suppurativa — large and growing biologics market • Metabolic/inflammatory disease potential • Possible CNS applications And separately, Monte Rosa’s broader molecular-glue platform includes MRT-6160/DDY391, partnered with Novartis and now advancing into Phase 2 Sjögren’s disease, plus MRT-2359 in AR-mutant prostate cancer. My bar tomorrow: CRP alone probably isn’t enough. A clean safety profile + deep NEK7 degradation + reproducible CRP suppression plus movement in biomarkers upstream/beyond CRP would be much more important. That would strengthen the argument that degrading NEK7 is biologically different from simply targeting a downstream cytokine — and could materially de-risk MRT-8102 as a multi-indication inflammatory franchise. Tomorrow is still only short-duration biomarker data — not clinical outcomes. But if the biology holds across doses and multiple layers of the pathway, that’s exactly the kind of translational signal I want to see. NFA | DYOR

$GLUE everyday it’s a grind down on lower than average volume. Picking up in tranches but would love a turnaround soon

$GLUE Good post! If you check out my recent VSTM youtube video link posted in twits, I scroll through the Chinese patent - thousands of compounds. Between Genfleet and Wuxi - for every on chemist here or in Europe, it seems there are 10 Chinese - years ago I would have dismissed the competition, but not now. Separately, GLUE is moving / drifting down exactly as I predicted in the spring - pressure from summer doldrums plus those holding 300% gains but waiting to seal in profit as 1 year long term capital gains so I am seeing downward pressure continuing. Plus, that whole sell off based on vicarious news was really fishy to me, and the blip but no follow through with the impressive another $50M payment also seems curious, if not a harbinger.

$GLUE — I think the market is dramatically underappreciating what MRT-8102 just showed. This wasn’t simply “CRP went down.” After only 4 weeks of oral therapy, MRT-8102 produced ~80–90% NEK7 degradation and hit an extraordinary number of inflammatory, atherogenic and thrombogenic biomarkers: • hsCRP ↓85% • IL-6 ↓54% • Calprotectin ↓56% • S100A12 ↓46% • SAA ↓51% • Fibrinogen ↓28% • Lp(a) ↓24% • HMGB1 ↓40% in high-baseline subjects • IL-1β ↓37% in high-baseline subjects Several biomarkers moved toward levels seen in healthy volunteers. Now consider the human validation. CANTOS previously demonstrated that IL-1β inhibition could reduce CV events. Low-dose colchicine—which indirectly affects NLRP3/inflammation—is already FDA approved for reducing cardiovascular events. Meanwhile Novo’s ziltivekimab produced major IL-6/CRP suppression but recently FAILED Phase 3 ZEUS on MACE (HR 0.99) and had more serious infections. That’s precisely why MRT-8102 is fascinating. Rather than blocking ONE downstream cytokine, $GLUE is degrading NEK7 upstream of NLRP3, potentially suppressing multiple pathogenic outputs simultaneously. And so far: No SAEs. No observed increased infection risk. TEAEs 33% vs 30% placebo. Oral small molecule. Obviously 4-week Phase 1 biomarker data ≠ clinical efficacy. Phase 2 must prove this translates into plaque modification and ultimately outcomes. But the commercial opportunity if it does is enormous. ASCVD: ~18.7M U.S. patients; ~60% reportedly have CRP >2 mg/L → roughly 11M residual-inflammatory-risk patients. Even a hypothetical $5,000/year × 5% penetration of that population = ~$2.8B annual U.S. revenue opportunity. And ASCVD isn’t the entire MRT-8102 opportunity: GOUT: 9.2M U.S. adults. At $5K/year × only 5% penetration = **$2.3B theoretical annual revenue.** HIDRADENITIS SUPPURATIVA: estimates approaching ~2.9M U.S. patients, with the U.S. treatment market projected around $5.4B by 2034. Approved HS biologics include Humira, Cosentyx and Bimzelx, while Merck just reported strong Phase 2 tulisokibart data. MRT-8102 could potentially bring something very different: oral + upstream + multi-biomarker suppression + encouraging early safety. ASCVD + gout + HS creates a potential multi-billion-dollar franchise if Phase 2 converts this extraordinary pharmacology into clinical efficacy. The biggest question is no longer whether MRT-8102 engages NEK7/NLRP3. It clearly does. The multibillion-dollar question is whether this remarkably broad biological response translates into disease modification. GFORCE-2 may be one of the most important Phase 2 studies in the $GLUE pipeline. For research/discussion only. Revenue examples are illustrative assumptions, not forecasts.

$GLUE and sustained NEK7 degradation observed across 5 mg, 20 mg, and 40 mg once-daily dose levels, with similar biomarker reductions at all three doses HMGB1, calprotectin, S100A12, and SAA, damage-associated molecular patterns (DAMPs) linked to atherosclerotic plaque progression and instability, and IL-1β, all established key pathogenic drivers of ASCVD, were reduced to levels comparable to normal physiological levels seen in the healthy volunteer population of Phase 1 study

$GLUE Monte Rosa Therapeutics initiated with a Buy at H.C. Wainwright H.C. Wainwright initiated coverage of Monte Rosa Therapeutics with a Buy rating and $25 price target. The company is undervalued at a $565M enterprise value given its two wholly-owned clinical assets, partnered Phase 2 asset, and near-term readouts, the analyst tells investors in a research note. H.C. Wainwright sees Monte Rosa as undervalued as it "approaches multiple inflection points, with multiple shots on goal for asymmetric upside."

$GLUE They are developing a very deep pipeline with unique targeting and genetic target hits with what looks like good efficacy so far. Would add or start a position here, half the market cap is in cash with big time partners. Probably worth 4 times once one of those first few drugs move into phase 3.

$GLUE - like the gap up from bottom pattern on POC validation for their NEK7 target (safe degradation + reduction in key DAMPs & cytokines). Broad development program reflects mgmt confidence

8AM ET clinical-results webcast 4-hour chart shows a rebound within a downtrend 13.84 hold 14.40 / 14.81 / 14.99 overhead Wait for the results reaction and a higher low before entry… $GLUE

$GLUE "The presentation will include safety and activity data for MRT-8102 across multiple dose levels following 4 weeks of treatment and will showcase pioneering data on the modulation of multiple pathogenic drivers of atherosclerotic cardiovascular disease (ASCVD) by MRT-8102." Pioneering data. Hmmmmm

$GLUE: Monte Rosa Therapeutics reported positive Phase 1 MRT-8102 data showing sustained NEK7 degradation, biomarker reductions, and no serious adverse events.