
• Reported GAAP EPS of $1.17 up 1000.00% YoY • Reported revenue of $406.56M up 209.09% YoY • BioCryst maintained full year 2026 global net ORLADEYO revenue guidance between $625M and $645M. BioCryst also maintained 2026 total revenue guidance between $635M and $660M.
Bullish
BioCryst achieved record profitability and strong ORLADEYO revenue in 2025, expanded its HAE portfolio through acquisition, and advanced its pipeline with FDA approval for ORLADEYO pellets and positive navenibart trial results.
Bearish
BioCryst recorded a $17.3M loss on debt extinguishment in 2025, experienced increased GAAP operating expenses, and faces risks in pipeline development timelines and regulatory approvals.