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Ondas Holdings, Inc. engages in the development, marketing, and sale of wireless radio systems for secure, wide area mission-critical business-to-business networks. It operates through the Ondas Networks and Ondas Autonomous Systems segments. The Ondas Networks segment provides wireless connectivity solutions enabling mission-critical Industrial Internet applications and services. The Ondas Autonomous Systems segment designs, develops, and markets commercial drone solutions via the Optimus System and Scout System. The company was founded on December 22, 2014 and is headquartered in Boston, MA.

Ondas Holdings Inc

Ondas Holdings is trending due to its acquisition of Sentrycs, a counter-UAS technology firm, sparking discussions about the company's expanded capabilities in the drone defense sector. Community members are debating the potential impact of this acquisition on future contracts and revenue, especially with the government shutdown affecting the timing of potential deals. Concerns remain around dilution and historical stock behavior, leading to a battle between bullish and bearish sentiments.

Internet Computer (IC) is the world’s first blockchain that is capable of running at web speed at unrestrictive capacities. Built by the DFINITY Foundation, IC aims to recreate the web by supporting smart contract development at scale and changing the way people can interact using web services. Internet Computer aims to extend the public internet, so that it can be the world’s computing platform, in a decentralized manner. Internet Computer sets to revolutionalize the design of the crypto economy, with an aim to overhaul traditional software services.   The project was founded in October 2016 by Dominic WIllams and have raised a total of $121 million from investors such as Adreessen Horowitz, Polychain Capital, Multicoin Capital and such. On May 10, 2021, DFINITY launched the Internet Computer into the public domain, marking it a major milestone for ICP as it means the internet now functions as a decentralised global computer. This is marked by the release of all of the Internet Computer’s source code into the public domain, as well as ICP utility token that allows tens of thousands of community members to govern the Internet Computer network.  ICP is Internet Computer's native token. It plays three prominent roles:  1. Network Governance: Users that participate in the governance will be rewarded with ICPI 2. Production of Cycles for Compute: ICP can be converted into cycles where it is used as the transaction fee to access the network. Cycles are burned after used. 3. Rewarding Users: ICP is used as the rewards to incentivize users to participate in the network such as securing the network.

Internet Computer

Internet Computer (ICP) is trending as community members discuss its potential to disrupt the traditional IT tech stack, with some drawing comparisons to early Bitcoin. Bullish sentiment is fueled by recent volume spikes and the integration of AI capabilities, specifically the Caffeine AI platform. Community members are speculating on price targets, with some anticipating a substantial run-up, while others caution against the token's history and potential pullbacks.

Welcome to SLAP – The Only Coin That Slaps Harder Than Your Moms  Tired of coins that claim they SLAP but are nothing but limp wrists? SLAP is here to SLAP some sense into the crypto space.  Founded by the Flutter of Five Fingers and powered by the Prancing of the Pried Palm, SLAP isn’t just another coin—it’s an attitude.  We’re not here to talk roadmaps, utility, or world peace. We’re here to SLAP charts, SLAP the haters, and SLAP our way to the top. No VC suits, no corporate nonsense—just raw, unfiltered internet culture with a side of “did we just do that?  ”So load your wallet, mute your financial advisor, and get ready to ride the most unhinged meme rocket. Open up your hands, and start swingin'. You never know what you could hit.  SLAP: It’s not a coin. It’s a lifestyle.

Slap

$SLAP is trending as community members express bullish sentiment and promote the project. Active discussions revolve around its potential and daily presence, with many users using the term "slap" as a positive affirmation. Some community members highlight its association with other tokens like $BROKE, $CAW, $RAGE, and $WAGMI.

Sui is an innovative layer-1 blockchain platform crafted to meet the demands of global adoption, providing a secure, robust, and scalable development environment. Rooted in a unique object-centric data model and fortified by the trusted Move programming language, Sui is engineered to tackle the inefficiencies found in current blockchain frameworks.  In addition to its solid technical underpinnings, Sui places a strong emphasis on user experience, aiming to remove common barriers encountered in blockchain interactions. Through groundbreaking features such as zkLogin, sponsored transactions, and programmable transaction blocks, Sui sets a new standard for user accessibility and friendliness within Web3 applications.  Unique elements of Sui Sui’s innovative architecture ensures swift transactions with stable fees and high throughput through horizontal scaling. Its object-oriented design offers deep composability for developers, enabling tailored object types with network-wide compatibility. This revolutionizes asset and protocol collaboration, fostering product innovation.  The platform's object-oriented approach dramatically improves transaction processing, enabling parallel execution and faster completion times. Additionally, unique consensus requirements expedite transaction finalization while maintaining stability. Sui prioritizes overcoming Web3 adoption barriers, offering native tools like zkLogin and sponsored transactions for wallet onboarding and fee management.  Move integration into Sui's data model combines innovation with security, mitigating common exploits found in smart contract languages. This empowers developers and users with a secure and intuitive platform, accelerating the evolution of Web3 applications.  About the Sui token The SUI token serves four primary functions within the Sui ecosystem: Proof-of-stake participation - Sui implements a delegated proof-of-stake mechanism, rewarding honest behavior by validators and SUI token holders who stake with them. Gas fee payments - SUI tokens cover gas fees for executing transactions and storing data onchain. Application utility - SUI is a versatile asset, integral to various applications within Sui’s ecosystem, including decentralized exchanges, lending platforms, gaming, and more. Governance - The SUI token empowers holders to participate in on-chain voting on significant matters like protocol upgrades and platform changes, shaping the future of Sui.  Additionally, the Sui storage fund ensures fair compensation for validators by distributing stake rewards over time and covering storage costs for previously stored on-chain data. This tokenomic strategy promotes indefinite data storage while maintaining fair compensation for validators, fostering long-term sustainability.

SUI is trending as the community discusses potential breakouts and accumulation opportunities, with some viewing current prices as a steal.  Enthusiasm is fueled by developments within the SUI network, including new partnerships and integrations in GameFi, DeFi, and NFTs, with some drawing comparisons to Solana's earlier growth.

Sezzle, Inc. engages in the operation of a digital payment platform that enables bank-to-bank transfer of money between consumers and businesses. The company was founded by Charlie G. Youakim, Killian Brackey and Paul V. Paradis on January 4, 2016 and is headquartered in Minneapolis, MN.

Sezzle Inc.

Sezzle Inc. is trending as investors assess its potential amid broader market volatility and upcoming events like the Klarna IPO. Community discussions focus on the stock's current valuation relative to its growth and profitability metrics, with some anticipating a strong performance in Q3 and Q4. Despite a recent dip, long-term bulls remain confident in Sezzle's fundamentals and its position within the BNPL sector.

Polkadot is a platform that allows diverse blockchains to transfer messages, including value, in a trust-free fashion; sharing their unique features while pooling their security. In brief, Polkadot is a scalable heterogeneous multi-chain technology.  Polkadot is heterogeneous because it is entirely flexible and makes no assumption about the nature or structure of the chains in the network. Even non-blockchain systems or data structures can become parachains if they fulfill a set of criteria.  Polkadot may be considered equivalent to a set of independent chains (e.g. a set containing Ethereum, Ethereum Classic, Namecoin and Bitcoin) except with important additions: pooled security and trust-free interchain transactability.  Many of the native parachains of Polkadot will be written using a Polkadot Runtime Environment SDK (e.g. Parity Technologies' Substrate).

Polkadot

Polkadot is trending as the community discusses potential catalysts like a spot ETF and the implications of a new 2.1 billion token cap. Community members are weighing the potential for significant price movement against concerns about past performance and project leadership. Staking rewards and interoperability with projects like Aventus ($AVT) are also being actively discussed.

Anavex Life Sciences Corp. is a clinical stage biopharmaceutical company, which engages in the development of different therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases. Its lead compound, ANAVEX2-73, is being developed to treat Alzheimer's and Parkinson's disease and central nervous system diseases, including Rett syndrome. The company was founded by Harvey Lalach and Athanasios Skarpelos on January 23, 2004 and is headquartered in New York, NY.

Anavex Life Sciences Corporation

Anavex Life Sciences Corp

AVXL is trending as investors eagerly await the upcoming CHMP opinion on Blarcamesine for Alzheimer's, with community discussions focused on potential approval catalysts and partnership opportunities. Community members are debating the likelihood of a positive outcome given the drug's safety profile and efficacy data, as well as the potential for a short squeeze. The stock's price movement and trading volume are being closely monitored in anticipation of the regulatory decision.

Kazia Therapeutics Ltd. is an oncology-focused biotechnology company, which engages in the business of pharmaceutical drug development. The company was founded by Graham Edmund Kelly in March 1994 and is headquartered in Sydney, Australia.

Kazia Therapeutics Limited - ADR

Kazia Therapeutics

KZIA is trending as the community discusses positive preclinical data for its drug, Paxalisib, in treating triple-negative breast cancer, specifically noting its potential to overcome immunotherapy resistance; some are also awaiting further trial results and considering potential partnerships. Community members highlight the stock's low float and potential for a short squeeze, while others express caution regarding the company's financials. Despite mixed sentiment, there's anticipation for upcoming catalysts related to the drug's development and regulatory pathway.

The Filecoin network achieves staggering economies of scale by allowing anyone worldwide to participate as storage providers. It also makes storage resemble a commodity or utility by decoupling hard-drive space from additional services. On this robust global market the price of storage will be driven by supply and demand, not corporate pricing departments, and miners will compete on factors like reputation for reliability as well as price.

Filecoin

Filecoin is trending as traders discuss its potential as a decentralized storage solution and its possible connection to AI and data infrastructure projects. Community members are weighing in on price predictions and whether it can reach previous highs, while some compare it to competitors and other cryptocurrencies. Overall sentiment is mixed, with some expressing long-term bullishness and others citing concerns about its past performance.

Sei is a high-performance Layer 1 blockchain that scales the EVM with parallelized execution, enabling faster transactions, low fees, and seamless smart contract deployment. Sei removes traditional blockchain bottlenecks while maintaining full Ethereum compatibility. The upcoming Giga upgrade will deliver 50x improvements in EVM throughput, optimizing execution, consensus, and storage to push blockchain performance to web2 levels.

SEI is trending amid discussions about its potential, comparisons to other Layer-1 blockchains like Solana and SUI, and news of recent developments in its ecosystem. Community members are actively debating its current price, future growth prospects, and potential listings, with some viewing it as undervalued given its technology.

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<ul class="summary-bullets"><li>Spirit of the Coast Analytics said Anavex’s Alzheimer’s drug Blarcamesine is likely to gain conditional marketing authorization (CMA) from the European Medicines Agency, citing strong long-term efficacy data despite limited trial size.</li><li>The report projected tens of billions in peak sales potential and said Anavex would likely require a big-pharma partnership to achieve full commercialization.</li><li>On Stocktwits, traders praised the analysis as “best in class,” with some predicting off-label use across other dementia types and urging patience for long-term gains.</li></ul>Anavex Life Sciences shares drew some retail chatter on Tuesday after a new report from Spirit of the Coast Analytics projected that the company’s lead Alzheimer’s drug, Blarcamesine, could secure conditional approval in Europe and attract a major pharmaceutical partner to accelerate commercialization.<h2 class="st-heading-2">EMA Conditional Approval Expected</h2>Spirit of the Coast Analytics&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.sotcanalytics.com/update-compendium-2025#h.j7yb7yv7gs20">said</a> it believes Blarcamesine is “likely (though not definitive)” to receive conditional marketing authorization (CMA) from the European Medicines Agency (EMA). The report said the EMA often prefers granting conditional approval rather than outright denial for drugs addressing major unmet medical needs, particularly when data show large effect sizes.Analysts noted that Blarcamesine’s existing Phase 2b/3 data, while limited in sample size and missing one co-primary endpoint, showed statistically strong results and sustained efficacy over 192 weeks in long-term studies. The report emphasized that any conditional approval would reflect “incomplete” data, not doubts over validity.<h2 class="st-heading-2">Market Potential And Pricing Forecasts</h2>The report projected that Blarcamesine could capture up to 40% market share among early-stage Alzheimer’s patients across the U.S. and Europe, translating into tens of billions in potential revenue at peak.Spirit of the Coast estimated that the drug’s price could range between $10,000 and $18,200 per year in the U.S. and $8,000 and $14,000 in Europe, based on quality-adjusted life year (QALY) analysis. The analysts said the drug’s oral delivery, strong safety profile, and lack of complex monitoring requirements would support broad adoption and payer acceptance.<h2 class="st-heading-2">Partnership Pathway Viewed As Essential</h2>The report said Anavex “almost certainly requires a big-pharma partnership” to achieve its commercial potential. Analysts projected a possible multi-billion-dollar upfront payment with tiered royalty milestones under such a deal, noting that large pharmaceutical companies would likely seek to collaborate given the drug’s market opportunity and safety data.The report also said a partnership could accelerate regulatory engagement and manufacturing scale-up, allowing Anavex to compete more effectively against higher-priced monoclonal antibody therapies such as Leqembi and Kisunla.<h2 class="st-heading-2">Stocktwits Traders See Upside But Cautious On Long-Term Gains</h2>On Stocktwits, retail sentiment for Avanex was ‘bearish’ amid ‘normal’ message volume.One user called the analysis “best in class,” saying it highlighted “super-massive potential” for Blarcamesine, including off-label use in other dementias, and urged investors to “strap in” for the long term rather than selling early.<stembedurl>https://stocktwits.com/Veliger/message/633171391</stembedurl>Another user said the projections seemed “mathematically sound” but warned of a “fantasyland vibe,” estimating a 90% chance of approval and noting that retail investors’ gains may hinge on whether Anavex opts for a partnership or a buyout.<stembedurl>https://stocktwits.com/ItsThrillhouse/message/633175141</stembedurl><a href="https://stocktwits.com/symbol/AVXL">Avanex’s stock</a> has declined 13% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

Avanex’s stock has declined 13% so far in 2025. (Photo credit: Getty Images)

Anavex Life Sciences Stock Sparks Retail Banter On Hopes Of EMA Conditional Nod For Alzheimer's Drug, Big Pharma Tie-Up

The report projected tens of billions in peak sales potential and said Anavex would likely require a big-pharma partnership to achieve full commercialization.

Equity

Anavex Life Sciences (AVXL) on Thursday said that its investigational drug achieved its primary endpoint in a mid-stage trial and demonstrated safety and tolerability in adults with Schizophrenia.Shares of the company soared 9% in Thursday’s pre-market session.The company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/10/02/3160275/29248/en/Anavex-Life-Sciences-Announces-Positive-Topline-Results-from-Phase-2-Study-of-ANAVEX-3-71-for-the-Treatment-of-Schizophrenia.html">said</a> that the safety profile of ANAVEX3-71 was consistent with previous studies in healthy volunteers, and no serious treatment-emergent adverse events were reported in the study.The company is evaluating the drug in the treatment of Schizophrenia, a persistent and often disabling mental illness impacting how a person thinks, feels, and behaves, and affects nearly 24 million people worldwide. According to Anavex, the illness impacts 2.8 million people in the U.S. alone.On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/AVXL">AVXL stock</a> jumped from ‘neutral’ to ‘bullish’ over the past 24 hours, while message volume stayed at ‘high’ levels.Anavex also said on Thursday that encouraging trends were observed in biomarkers of Schizophrenia in the study that support continued development. This includes a reduced glial fibrillary acidic protein in patients receiving ANAVEX3-71 compared to placebo.GFAP is a marker of neuroinflammation, and a reduction in it suggests a potential disease-modifying effect that may become more pronounced with longer treatment durations, the company said.The company on Thursday also <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/10/02/3160281/29248/en/Anavex-Life-Sciences-Announces-Successful-Development-of-Once-Daily-Oral-Tablet-Formulation-for-the-ANAVEX-3-71-Program.html">announced</a> the successful development of a once-daily oral tablet formulation for the ANAVEX3-71 program. The tablet exhibits superior pharmacokinetics compared to the current immediate-release oral capsule, enabling once-daily dosing, it added.AVXL stock is down 16% this year but up approximately 59% over the past 12 months.&nbsp;Read also:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/rivian-slashes-full-year-delivery-guidance-after-drop-in-q3-figures/chCrfpbR3OH">Rivian Slashes Full-Year Delivery Guidance After Drop In Q3 Figures</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Rising stock market chart on a trading board background.

Anavex Life Sciences Stock Just Shot Up 7% Today – Here’s An Important Update

The company said that its investigational drug for Schizophrenia achieved its primary endpoint in a mid-stage trial.

Anavex Life Sciences Corp. (AVXL) on Tuesday announced that its experimental Alzheimer’s drug demonstrated cognitive stabilization in patients with early Alzheimer’s disease in a study.After 48 weeks, patients receiving 30 mg once-daily oral Blarcamesine in a precision medicine population demonstrated barely detectable cognitive decline on all standard scales for measuring cognitive decline, comparable to the minimal decline in pre-dementia aging adults.Shares of the company rose 2% on Tuesday morning at the time of writing. On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/AVXL">AVXL stock</a> jumped from ‘bearish’ to ‘neutral’ territory over the past 24 hours, while message volume rose from ‘low’ to ‘normal’ levels.The company <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.anavex.com/post/anavex-life-sciences-announces-oral-blarcamesine-cognitive-resilience-results-approximating-normal-a">said</a> that the drug caused about an 84.7% reduction in cognitive decline as compared to placebo on a standardized neuropsychological test used in Alzheimer's disease research to measure cognitive function.“Today’s new clinical efficacy data update from our Phase IIb/III trial is critical, as it adds contemporary context to Precision Medicine data showing strong protection from Alzheimer’s disease with an oral once-daily potential solution with the aim to alleviate significant medical and economic burden,” said Juan Carlos Lopez-Talavera, Head of Research and Development of Anavex.Anavex will continue to evaluate trial data, which will be published and presented at international conferences, the company said.Anavex is also studying Blarcamesine, its lead candidate, in dementia caused by Parkinson's disease, a neurodegenerative brain condition, and in patients with Rett syndrome, a rare genetic neurological and developmental disorder that affects the way the brain develops.AVXL stock is down 12% this year but up approximately 84% over the past 12 months.&nbsp;Read also: <a href="https://stocktwits.com/news-articles/markets/equity/ford-recalls-nearly-1.5-million-vehicles-in-us/chwKduPRdte">Ford Draws Retail Investor Concerns After It Recalls Nearly 1.5M Vehicles In US Over Rear View Camera Display Issues</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

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Anavex Life Sciences Stock Rises After Experimental Alzheimer’s Drug Slows Cognitive Decline In Study

After 48 weeks, patients receiving 30 mg once-daily oral Blarcamesine demonstrated barely detectable cognitive decline, the company said. 

Anavex Life Sciences slipped in after-hours trading on Monday after the company said it plans to raise&nbsp;as much as $300 million by selling shares.The stock closed at $11.48 on Monday, up 3.3% for the day, before slipping 1% to $11.37 in after-hours trading.The stock offering comes on the heels of its latest quarterly results,&nbsp;which showed net loss was $11.2 million, or $0.13 a share, compared with a loss of $10.5 million in the same period last year.&nbsp;The company had $115.8 million in cash at the end of March and said that it would fund the company for about four years.In April, Anavex disclosed an update on the long-term data on its Alzheimer’s candidate, blarcamesine. According to new data released, the drug slowed cognitive decline in early-stage Alzheimer’s patients over&nbsp;four years.&nbsp;The results were disclosed at the AD/PD 2025 conference, and they hint that the treatment may have a disease-modifying effect if started early and taken continuously.The drug has also been well tolerated. No&nbsp;significant safety issues were reported, and dizziness, the most common side effect, was reduced by tweaking the dose schedule.Anavex has also wrapped up enrollment for a mid-stage trial of its schizophrenia drug, Anavex 3-71, with results expected in the second half of the year.&nbsp;Separately, 74 patients remain on long-term blarcamesine therapy through a Compassionate Use Program, with some having taken the drug daily for over nine years.On Stocktwits, retail sentiment for Anavex was ‘extremely bullish’ amid ‘high’ message volume.One user viewed the shelf registration as a bullish signal, suggesting that Anavex may be positioning itself for a potential EMA approval.&nbsp;They speculated the filing could be tied to plans for standalone distribution or as a strategic move to strengthen the company’s hand in partnership talks, calling it “nothing but good news” for long-term holders.<stembedurl>https://stocktwits.com/PartyNaked/message/620947957</stembedurl>Another user said that the S-3 filing doesn’t mean an immediate offering, but rather gives the company flexibility to raise funds if needed, particularly after a major catalyst like an EMA decision.&nbsp;They called the move smart and standard for biotech firms, arguing it allows Anavex to act quickly if the stock jumps post-approval and strengthens its negotiating position with potential partners.<stembedurl>https://stocktwits.com/kay91667/message/620942567</stembedurl>Anavex’s stock has declined 5.5% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

Avanex Life Sciences (AVXL) said it plans to raise up to $300 million by selling shares. (Photo credit: Getty Images)

Anavex Life Sciences Stock Falls After Hours On $300M Raise Plan; Retail Traders Think It’s A ‘Smart’ Move 

The after-hours move followed Anavex’s recent completion of enrollment for a mid-stage schizophrenia trial, with top-line results expected later this year. 

Are You Looking for a Top Momentum Pick? Why Anavex Life Sciences (AVXL) is a Great Choice

Does Anavex Life Sciences (AVXL) have what it takes to be a top stock pick for momentum investors? Let's find out.

Are Medical Stocks Lagging  Adaptive Biotechnologies (ADPT) This Year?

Here is how Adaptive Biotechnologies (ADPT) and Anavex Life Sciences (AVXL) have performed compared to their sector so far this year.

Check out the top five trending stocks on Stocktwits on Wednesday as U.S. equity markets recover after taking a breather on Tuesday. The stocks trending the most on the Stocktwits platform include Webull, SharpLink, Anavex Life Sciences, BigBear.ai, and Oscar Health.1. Webull Corp. (BULL)<img src="https://news.stocktwits-cdn.com/BULL_png_3a86d4a0fc.webp" alt="BULL.png">2. SharpLink Gaming Ltd. (SBET)<img src="https://news.stocktwits-cdn.com/SBET_png_ddf51dbef1.webp" alt="SBET.png">3. Anavex Life Sciences Corp. (AVXL)<img src="https://news.stocktwits-cdn.com/AVXL_png_b962881047.webp" alt="AVXL.png">4. BigBear.ai Holdings Inc. (BBAI)<img src="https://news.stocktwits-cdn.com/BBAI_png_3156927dd7.webp" alt="BBAI.png">5. Oscar Health Inc. (OSCR)<img src="https://news.stocktwits-cdn.com/OSCR_png_e8f637dd66.webp" alt="OSCR.png">Disclaimer: Stocktwits' "Why It's Trending" summary is AI-generated and may contain errors.For updates and corrections, email newsroom[at]stocktwits[dot]com.Also See:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/trump-us-make-fortune-if-big-beautiful-bill-is-passed-but-house-republicans-could-sink-it/chF0ot3RTyE">Trump Says US Will ‘Make A Fortune’ If The Big Beautiful Bill Is Passed, But House Republicans Could Sink It</a>

Traders work on the floor of the New York Stock Exchange during morning trading on August 06, 2024 in New York City as the market opened after the worst crash since 2022

Top 5 Trending Stocks On Stocktwits Today: Webull, SharpLink, Anavex Life Sciences, BigBear.ai, And Oscar Health

Check out the top five trending stocks on Stocktwits on Wednesday as U.S. equity markets recover after taking a breather on Tuesday.

Lightning Round: Sell Viking Therapeutics, says Jim Cramer

'Mad Money' host Jim Cramer weighs in on stock including: Anavex Life Sciences, Sarepta Therapeutics, Viking Therapeutics, Transocean, and DuPont...

Anavex Life Sciences Corp., a small-cap biotech specializing in neurodegenerative and neurodevelopmental diseases, emerged as the top pick among retail investors in a recent Stocktwits poll.&nbsp;Nearly 45% of respondents believe Anavex will outperform in the first quarter of 2025, compared to 33% for Novavax and 9% for Rigel Pharmaceuticals.<stembedurl>https://stocktwits.com/StocktwitsPolls/message/599783274</stembedurl>Alzheimer’s Therapy MomentumAnavex has garnered attention for its investigational Alzheimer’s drug, blarcamesine (ANAVEX 2-73), whose European Marketing Authorization Application was&nbsp;<a href="https://stocktwits.com/news-articles/markets/5/avxl-stock-rises-on-q4-results-ema-nod-for-blarcamesine/cJazDmdRj5">accepted</a> last month.&nbsp;Promising trial results showed three years of continuous blarcamesine treatment significantly reduced clinical decline in early Alzheimer’s patients, with no safety issues reported.&nbsp;That positions the drug as a potential breakthrough, especially as interest in Alzheimer’s therapies intensifies following recent setbacks for rivals like Cassava Sciences.The company’s stock surged over 76% in 2024 but is down 6% year-to-date, with a high short interest of 24.5% as per Koyfin data.&nbsp;Anavex reported $132.2 million in cash reserves as of Sept. 30, 2024, and projects a four-year cash runway at its current burn rate.Vaccine Maker Eyes RecoveryNovavax has maintained momentum after a 68% gain in 2024, with shares up nearly 6% this year.&nbsp;The company&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/nvax-stock-is-undervalued-say-retail-investors/chGWtkSRZy">recovered</a> from an FDA clinical hold on its COVID-19 and flu combination vaccine late last year, thanks to a $50 million milestone payment under its Sanofi partnership and increasing hopes for a bird flu vaccine.&nbsp;Novavax holds the largest market cap among the three at $1.38 billion. It has $909.5 million in cash and a manageable debt load of $262 million, which many retail investors see as an advantage.&nbsp;It also has a high short interest of 24.5%.Under-The-Radar Bet?Rigel Pharmaceuticals focuses on autoimmune and hematologic diseases. The company recently received orphan drug designation for R289, a treatment for lower-risk myelodysplastic syndromes.&nbsp;A growing portfolio of approved therapies, such as TAVALISSE for chronic immune thrombocytopenia and REZLIDHIA for acute myeloid leukemia has also boosted retail sentiment.On Monday, the company said it expects fourth-quarter revenue of $57.6 million, up 61% year-over-year and above a Wall Street estimate of $47.4 million. It also projected 2025 revenue of $200-$210 million, better than an expected $193.5 million.Rigel’s stock rose 15% in 2024 and remained nearly flat in 2025. As of Dec. 31, 2024, it had estimated cash reserves of $77.3 million.&nbsp;Rigel’s short interest is relatively low at 3.6%.For updates and corrections, email newsroom[at]stocktwits[dot]com.

Anavex has garnered attention for its investigational Alzheimer’s drug, blarcamesine (ANAVEX 2-73). | Image source: Getty Images 

Retail Investors Bet On Anavex Lifesciences Stock To Outperform Novavax, Rigel Pharma In Q1 On Alzheimer’s Drug Buzz

The intense retail focus on Anavex reflects a broader market interest in neurodegenerative therapies, especially following disappointing trial results from Cassava Sciences’ simufilam.

Anavex Life Sciences Corp. shares rocketed over 27% on Monday, hitting their highest levels since February 2023, fueled by a mix of positive earnings results and regulatory progress in Europe.The biopharma company, focused on neurodegenerative and neurodevelopmental diseases, reported a fiscal fourth-quarter loss of $11.6 million, or an adjusted $0.14 per share, compared to a loss of $10.1 million in the year-ago period.&nbsp;While research and development (R&amp;D) and overhead costs rose, the per-share loss was narrower than the FactSet consensus estimate of $0.16.Anavex also highlighted a strong cash position, with $132.2 million in reserves, which the company says will provide a four-year runway at current burn rates.Creating more buzz was news that the European Medicines Agency (EMA) accepted the Marketing Authorization Application for blarcamesine (ANAVEX 2-73), an investigational oral drug for Alzheimer’s disease.&nbsp;Anavex’s Head of R&amp;D, Juan Carlos Lopez-Talavera, said: "The EMA filing acceptance for blarcamesine to review the Marketing Authorization Application potentially brings us a step closer offering broader patient access to a new treatment option in Europe, and we look forward to continued engagement with the EMA.”CEO Christoper Missling said, "We are excited about the potential to advance a novel treatment for early Alzheimer's disease with convenient oral dosing and our team remains deeply committed to executing on our momentum.”<figure class="image"><img style="aspect-ratio:1326/1056;" src="https://st-everywhere-cms-prod.s3.us-east-1.amazonaws.com/AVXL_poll_sentiment_and_message_volume_Dec_24_fe40cd4f12.png" alt="AVXL poll sentiment and message volume Dec 24.png" width="1326" height="1056"><figcaption>AVXL poll, sentiment and message volume on Dec 24 as of 1:30 pm ET | source: Stocktwits</figcaption></figure>Retail investors on Stocktwits celebrated the news, with sentiment shifting sharply to ‘bullish’ from ‘neutral.’&nbsp;Many hailed the EMA filing as a significant milestone, with one user claiming very high approval rates by the European regulator for “accepted drug candidates in 2024 that aren't withdrawn.”<stembedurl>https://stocktwits.com/Guzzi62/message/597573043</stembedurl><stembedurl>https://stocktwits.com/PhillipHerass/message/597572113</stembedurl><stembedurl>https://stocktwits.com/Logic102/message/597572650</stembedurl>According to a&nbsp;<a target="_blank" rel="noopener noreferrer nofollow" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10499418/">study</a> published last year in the Clinical and Translational Science, an official journal of the American Society for Clinical Pharmacology and Therapeutics, the EMA was found to have the highest approval rate (93.8%) for non-oncology products when compared with Swiss and U.S. regulators. The data analyzed decisions between 2009 and 2018 on new active substances.The broader market’s interest in Alzheimer’s therapies remains intense, particularly after Cassava Sciences&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/sava-stock-plunges-after-alzheimers-trial-fails/cJIf1KdRgh">reported</a> disappointing results for its candidate simufilam last month.&nbsp;D. Boral Capital had noted Anavex’s neuroprotective mechanism could position blarcamesine as a superior option, reiterating a ‘Buy’ rating with a $46 price target.Anavex shares are now up 88% year-to-date.For updates and corrections, email newsroom[at]stocktwits[dot]com.

EMA European Medicines Agency at Canary Wharf on 5th November 2024 in London, United Kingdom. (photo by Mike Kemp/In Pictures via Getty Images)

Anavex Sciences Soars On Earnings Relief, EU Filing Acceptance For Alzheimer’s Drug: Retail’s Overjoyed

The broader market’s interest in Alzheimer’s therapies remains intense, particularly after Cassava Sciences reported disappointing results for its candidate simufilam last month.

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Current Price	$7.21
Prev Close	$7.40
Open	$7.41
Dividend Yield	0.00%
50-Day Moving Average	$8.86
Beta	1.61
Avg. Volume	1.36M
PE Ratio	-12.87

52-Week High	$14.44
52-Week Low	$7.11
Market Capitalization	$626.17M
EPS (Annual)	-$0.5152
Price to Book	6.85
Revenue Per Employee	$0.00
Enterprise Value/EBITDA	N/A

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