10xorbust
$CABA the CEO really was impressive on today’s Morgan Stanley call. This is a MUST listen. Don’t rely on my summary or those of others.
One of the things that was new and different from the data that’s been released so far is the CEO discussed the safety differences between the two big Pharma programs of CAR-T that were paused due to deaths and severe complications (including the Novartis program marred by 3 deaths from side effects) and RESE-CEL cell by CABA. 
The CEO explained that the difference in safety originates from the length of manufacturing process. Apparently, the CAR-T therapies that resulted in very severe complications and deaths from these competing manufacturers involved manufacturing processes that were extremely short in duration - as short as two days - and apparently that truncated manufacturing produces cells that are much more likely to produce an inflammatory response and cause these kind of dangerous side effects. By contrast, RESE-CEL takes nine days to produce and as a result the cells are different and less likely to induce and inflammatory response.
This CEO also made clear that some types of diseases are not likely to be subject to preconditioning while others are.
The CEO again reiterated the company’s target of a BLA application for myositis, both for juveniles and adults, in the second half of 2027.
He said they’re still working on the higher dose for PV without preconditioning and that the higher dose is likely needed to ensure a more durable and consistent response.
He talked about the efficacy of the treatment in many of these autoimmune diseases and the numbers of people who basically were able to get off their steroids, and I believe the number was somewhere in the upper 80 percentile range for some diseases.
As I recall, what the CEO said is that the biggest differentiator between RESE-CEL is safety.  he talked about the emphasis on safety with things like the longer manufacturing process and how they haven’t seen these deaths or ultra severe side effects in patients that brought the other two competitors’ trials to a pause.
There was a lot of content and I’m only scratching the surface. It’s really a presentation every person must listen to themselves and do their own due diligence. Moreover, the CEO does a very good job at explaining technical concepts in simple to understand terms that people without significant medical training can grasp. 
That is always the mark to me anyway, of a leader with both competence and confidence. Liars tend to hide in jargon.
The bottom line is in 2027, there are going to be some very giant catalysts and it’s my personal opinion when those occur we will not see share prices anywhere near the high two dollar range.
To me, $CABA is in the accumulation stage with the major catalysts a good deal in the future in 2027 so this is the time to accumulate (at least for me) but not expect to make a killing in the new term. Investing in this stock will require a little bit of patience, which is fine for my investing style.
Nothing is certain in the stock market however and with a biotech like this, one big safety issue could sink the whole thing so I’m position sizing properly at 100,000 shares in relation to MY total portfolio. 
If someone tells me they are full porting into this or any other development stage biotech I’d probably slap them silly (figuratively, of course).
Good luck to the longs.
27
